Protein Details: Gamma-aminobutyric acid receptor subunit beta-1

Protein ID

ICDB_Pro_0374

Protein Name

Gamma-aminobutyric acid receptor subunit beta-1

Gene Name

GABRB1

Organism

Homo sapiens (Human)

Length

474 amino acids

AlphaFoldDB

AF-P18505-F1-model_v4.pdb

Function

Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA);a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels;also named GABA(A) receptors (GABAAR);consist of five subunits arranged around a central pore and contain one or two GABA active binding sites located at the alpha and beta subunit interfaces;depending on subunit composition (By similarity). When activated by GABA;GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential;thereby reducing nerve transmission. Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits;which may be involved in the regulation of sleep and wakefulness (By similarity).

Sequence

MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 122; /ligand="histamine": "ligand shared between two neighboring beta subunits"; /note="in chain B"; BINDING 181..182; /ligand="histamine": "ligand shared between two neighboring beta subunits"; /note="in chain B"; BINDING 182; /ligand="4-aminobutanoate": "ligand shared with the neighboring alpha subunit"; /note="in chain A"; BINDING 227; /ligand="4-aminobutanoate": "ligand shared with the neighboring alpha subunit"; /note="in chain A"; BINDING 227; /ligand="histamine": "ligand shared between two neighboring beta subunits"; /note="in chain B"

Disease

Developmental And Epileptic Encephalopathy and Early Infantile Epileptic Encephalopathy

Location

DOI ID

10.1016/0014-5793(89)80563-0; 10.1016/0888-7543(91)90189-l; 10.1038/ncomms4650; 10.1038/ng1285; 10.1038/nature03466; 10.1101/gr.2596504; 10.1002/ajmg.1320540105; 10.1073/pnas.96.17.9891; 10.1186/1471-2210-6-1; 10.1038/nature12439; 10.1002/ana.24699; 10.1002/ana.24631

RefSeq

NP_000803.2 [P18505-1]